What these compounds actually are

The one the EDS community asks about most. Animal data on tendon and gut healing is genuinely interesting; human data barely exists.

A fragment of a protein your body already makes. Human trials exist, which is unusual here, but they were for eyes and wounds rather than joints.

Strong evidence as a skin ingredient you put on. Much weaker evidence as something you inject.

Four compounds in one vial. Each has its own thin evidence base, and the combination has none at all.

KLOW without the KPV. Same situation: no studies of the combination.

The two repair peptides together. Popular in injury contexts; the pairing itself is untested.

Made it into real human trials, then was dropped. Selective, short-acting, and genuinely studied — just not approved.

A growth hormone releasing hormone analogue. The 'with DAC' version lasts days rather than minutes.

One of the few here that is an actual approved medicine — for a specific condition that is not hypermobility.

The compound behind Ozempic and Wegovy. Approved, extensively studied, and with a side-effect profile that matters a lot if you have EDS.

Dual GIP and GLP-1. Approved as Mounjaro and Zepbound. Same gastric emptying caution as semaglutide, and then some.

Triple agonist, still in Phase 3, not approved anywhere. The Phase 2 results were striking, which is exactly why caution matters.

A peptide your mitochondria encode themselves. Interesting biology, almost entirely animal evidence.

Named for an effect that later research struggled to reproduce consistently.

Approved in Russia, nowhere else. Most of the literature is in Russian and hard to appraise from outside.

A real and important antioxidant. Whether injecting it does more than eating well is the open question.

Not a peptide. A coenzyme central to energy metabolism, sold widely on the back of ageing research.

Another genuinely approved one, for a narrow indication.

The one with the clearest documented harms. Worth reading the risks before anything else.

Approved in a number of countries, though not the US. Mainly an immune modulator.